Second-placed City would have reduced Arsenal's advantage to two points but instead were frustrated as their winning streak in all competitions was halted at eight.
A summary of Saturday's action in the Premier League.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.
The Egypt forward has been left out of the club's Champions League match against Inter Milan.
Manchester United secured the point they needed to finish second in the Premier League with a dull 0-0 draw at West Ham United on Thursday.
Manchester United fought back to overpower West Ham United 3-1 and reach the FA Cup quarter-finals.
'...So that tells you the resilience, resources, the ambition the team has.'
Ruben Amorim is set to become the next manager of Manchester United with the Premier League club prepared to pay Sporting the 10 million euros ($10.79 million) release clause, the Portuguese club said on Tuesday.
Tottenham's task was made all the more difficult two minutes before the interval when forward Son Heung-min was sent off
A round-up of Saturday's action in the Premier League.
IMAGES from the Premier League matches played on Tuesday.
IMAGES from the UEFA Champions League matches played on Tuesday
Newcastle United registered a 2-0 home win over Chelsea on Sunday that moves the Magpies a step closer to Champions League football next season.
Premier League leaders Arsenal needed two own goals, the second deep in stoppage time, to scrape a 2-1 home win over bottom club Wolverhampton Wanderers and open a five-point gap, while earlier on Saturday Mohamed Salah put aside a tumultuous week to help Liverpool beat Brighton and Hove Albion 2-0.
Man United boss Amorim says he has no plans to quit
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Manchester United's troubled season hit a new low on Saturday as Jose Mourinho saw his gamble on introducing a new tactical system backfire with an insipid 3-1 defeat to West Ham United in the Premier League.
IMAGES from Premier League matches played on Sunday.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Nearly two decades later, Aditi Chauhan retires as a trailblazer, having become the first Indian woman to play professional football in Europe.
Daley Blind's injury-time equaliser rescued a 1-1 draw for Manchester United against West Ham United on Sunday but a point was not enough to regain third spot in the Premier League.
Tottenham Hotspur missed the chance to move into the top four when they were held to a 1-1 draw at West Ham United
Ruud van Nistelrooy will take over on an interim basis.
Images from Sunday's action in the Premier League
Fresh off a dominant title-winning campaign, Liverpool kick off the new Premier League season on Friday as the team to beat, as the Reds have transitioned from Juergen Klopp's high-octane chaos to a more measured possession-based style under Arne Slot.
Manchester United were humbled 3-0 at home by Newcastle United in the League Cup fourth round
West Ham United have condemned the behaviour of some of their fans after Fiorentina's Cristiano Biraghi was hit by a cup during the Europa Conference League final.
A brilliantly-worked goal by Ryan Christie and a Justin Kluivert penalty gave Bournemouth shock 2-0 Premier League win at home to 10-man Arsenal.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
Pep Guardiola has apologised to Kalvin Phillips for saying the midfielder was overweight
Sunderland and West Bromwich Albion stayed in touch with the Premier League leaders with solid home wins over West Ham United and Newcastle United on Sunday.
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
Manchester City took another decisive step toward an unprecedented fourth successive Premier League title with a 4-0 demolition of Fulham.
IMAGES from the Premier League matches played on Tuesday.
Images from the English Premier League matches played on Sunday.
Ryan Giggs scored a sublime goal to seal a 1-0 win for Manchester United at West Ham United on Sunday that sent them back to the top of the Premier League.
Manchester United suffered a stinging 2-1 home defeat by Swansea City in the FA Cup third round on Sunday as their former fortress of Old Trafford was ransacked for the fifth time this season.
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
Manchester United clinched a sixth consecutive Premier League win for the first time since April 2015 as Juan Mata and Zlatan Ibrahimovic scored second-half goals in a controversial 2-0 victory at 10-man West Ham United on Monday.
Manchester United closed in on the Premier League's pole position after a 2-1 home win over Aston Villa on Friday put them level on points and games played with champions and leaders Liverpool.